Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 29671-92-9, name is Carbamimidic chloride hydrochloride, A new synthetic method of this compound is introduced below., Computed Properties of CH4Cl2N2
To a suspension of Ig (400 mg, 0.66 mmol) in methanol (26 mL) was dropwise added concentrated HCl (4.5 mL) while stirring. The mixture was stirred at room temperature for 1 h. The resulting solution was concentrated in vacuo and dried. The residue was then mixed with methyl sulfone (6 g) and chloroamidine hydrochloride (113 mg, 0.99 mmol) in a microwave vial, and heated at 150 0C for 1 h. While cooling to room temperature, the mixture was treated with IN ammonium hydroxide (5 mL) and ethyl acetate (5 mL) with vigorous stirring. The organic layer was concentrated and the residue was purified by silica gel column chromatography (EtOAc / hexanes), affording 3a as an oil (0.05 g, 13%). MS = 584.0 (M+ H+). 1H NMR (300 MHz, CDCl3): B 8.09 (s, IH), 7.2-7.4 (m, 15H), 5.33 (s, IH), 4.4-4.8 (m, 7H), 3.96 (m, IH), 3.86 (m, 2H), 1.16 (s, 3H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; GILEAD SCIENCES, INC.; BUTLER, Thomas; CHO, Aesop; KIM, Choung, U.; XU, Jie; WO2010/93608; (2010); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics