Reporter Protein-Targeted Probes for Magnetic Resonance Imaging was written by Strauch, Renee C.;Mastarone, Daniel J.;Sukerkar, Preeti A.;Song, Ying;Ipsaro, Jonathan J.;Meade, Thomas J.. And the article was included in Journal of the American Chemical Society in 2011.Computed Properties of C6H12BrCl The following contents are mentioned in the article:
Contrast agents for magnetic resonance imaging are frequently employed as exptl. and clin. probes. Drawbacks include low signal sensitivity, fast clearance, and nonspecificity that limit efficacy in exptl. imaging. In order to create a bioresponsive MR contrast agent, a series of four Gd(III) complexes targeted to the HaloTag reporter were designed and synthesized. HaloTag is unique among reporter proteins for its specificity, versatility, and the covalent interaction between substrate and protein. In similar systems, these properties produce prolonged in vivo lifetimes and extended imaging opportunities for contrast agents, longer rotational correlation times, and increases in relaxivity (r1) upon binding to the HaloTag protein. The authors report a new MR contrast probe, 2CHTGd, which forms a covalent bond with its target protein and results in a dramatic increase in sensitivity. A 6-fold increase in r1, from 3.8 to 22 mM-1 s-1, is observed upon 2CHTGd binding to the target protein. This probe was designed for use with the HaloTag protein system which allows for a variety of substrates (specific for MRI, florescence, or protein purification applications) to be used with the same reporter. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Computed Properties of C6H12BrCl).
1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Computed Properties of C6H12BrCl
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics