Cobalt Bis(dicarbollide) Alkylsulfonamides: Potent and Highly Selective Inhibitors of Tumor Specific Carbonic Anhydrase IX was written by Gruener, Bohumir;Kugler, Michael;El Anwar, Suzan;Holub, Josef;Nekvinda, Jan;Bavol, Dmytro;Ruzickova, Zdenka;Pospisilova, Klara;Fabry, Milan;Kral, Vlastimil;Brynda, Jiri;Rezacova, Pavlina. And the article was included in ChemPlusChem in 2021.Reference of 75-57-0 The following contents are mentioned in the article:
Carbonic anhydrase IX (CAIX) is an enzyme expressed on the surface of cells in hypoxic tumors. It plays a role in regulation of tumor pH and promotes thus tumor cell survival and occurrence of metastases. Here, derivatives of the cobalt bis(dicarbollide)(1-) anion are reported that are based on substitution at the carbon sites of the polyhedra by two alkylsulfonamide groups differing in the length of the aliphatic connector (from C1 to C4, n = 1-4), which were prepared by cobalt insertion into the 7-sulfonamidoalkyl-7,8-dicarba-nido-undecaborate ions. Pure meso- and rac-diastereoisomeric forms were isolated. The series is complemented with monosubstituted species (n = 2). Synthesis by a direct method furnished similar derivatives (n = 2, 3), which are chlorinated at the B(8,8â? boron sites. All compounds inhibited CAIX with subnanomolar inhibition constants and showed high selectivity for CAIX. The best inhibitory properties were observed for the compound with n = 3 and two substituents present in rac-arrangement with Ki = 20 pM and a selectivity index of 668. X-ray crystallog. was used to study interactions of these compounds with the active site of CAIX on the structural level. This study involved multiple reactions and reactants, such as Tetramethylammonium chloride (cas: 75-57-0Reference of 75-57-0).
Tetramethylammonium chloride (cas: 75-57-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Reference of 75-57-0
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics