Microwave-assisted synthesis and antifungal activity of coumarin[8,7-e][1,3]oxazine derivatives was written by Zhang, Ming-Zhi;Zhang, Rong-Rong;Yin, Wen-Zheng;Yu, Xiang;Zhang, Ya-Ling;Liu, Pin;Gu, Yu-Cheng;Zhang, Wei-Hua. And the article was included in Molecular Diversity in 2016.Name: 4-Chlororesorcinol The following contents are mentioned in the article:
The synthesis of novel coumarin[8,7-e][1,3]oxazine derivatives I (R = C6H5, 4-H3CC6H4, 4-ClC6H4, CH2C6H5; R1 = H, Cl; R2 = CH3, C6H5, CF3; R3 = H, Me) through a microwave-assisted three-component one-pot Mannich reaction have been described in this study. All the target compounds I were evaluated in vitro for their antifungal activity against Botrytis cinerea, Colletotrichum capsici, Alternaria solani, Gibberella zeae, Rhizoctonia solani, and Alternaria mali. The preliminary bioassays showed that I (R = C6H5, 4-ClC6H4; R1 = Cl; R2 = CH3, CF3; R3 = H, CH3) exhibited good antifungal activity and the most active compound I (R = C6H5; R1 = Cl; R2 = CF3; R3 = H) shows an EC50 value as low as 2.1 nM against Botrytis cinerea. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Name: 4-Chlororesorcinol).
4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Name: 4-Chlororesorcinol
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics