An efficient synthesis of 6-arylpyrazolo[4′,3′:4,5]pyrimido[2,1-a] isoquinolin-8(9H)-one derivatives catalyzed by AgOTf was written by Pan, Wan-Chen;Li, Tuan-Jie;Liu, Jian-Quan;Wang, Xiang-Shan. And the article was included in Journal of Heterocyclic Chemistry in 2022.Application of 1186603-47-3 The following contents are mentioned in the article:
A new AgOTf-catalyzed domino reaction of 2-alkynylbenzaldehyde 1-CHO-2-(CCR)C6H3R1 (R = C6H5, 4-FC6H4, 4-CH3C6H4, etc.; R1 = 4-Cl, 5-F, 5-NO2, etc.) and 6-(2-phenylethynyl)-1,3-benzodioxole-5-carboxaldehyde and 4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide has been reported via a sequential condensation, cyclization, and acetylenic hydroamination process. The developed protocol provides an efficient and modular access to a range of new fused tetracyclic heterocycle 6-aryl-9-methyl-11-Pr pyrazolo[4′,3′:4,5]pyrimido[2,1-a]isoquinolin-8(9H)-ones I (R2 = H, Cl, F, Me; R3 = H, Cl, F, OMe, NO2; R2R3 = -OCH2O-) with two new rings in good yields. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Application of 1186603-47-3).
5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application of 1186603-47-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics