One pot, multicomponent protocol for the synthesis of novel imidazo[1,2-a]pyrimidine-based pyran analogs: a potential biological scaffold was written by Gungor, Tugba. And the article was included in Monatshefte fuer Chemie in 2020.Application In Synthesis of 4-Chlororesorcinol The following contents are mentioned in the article:
An efficient procedure between imidazo[1,2-a]pyrimidine-2-carbaldehyde, malononitrile, enolizable C-H activated acidic compounds, ROH (R = 3-hydroxyphenyl, 4-chloro-3-hydroxyphenyl, naphthalen-1-yl, etc.) dimedone and sodium carbonate is described for the synthesis of potential biol. active, novel imidazo[1,2-a]pyrimidine-based pyran analogs I (R1 = 7-OH, 6-Cl-7-OH, 7,8-CH=CHCH=CH) and II through one pot, multicomponent reactions at room temperature This method provided mild reaction conditions, simple purification without column chromatog., and moderate to good yields for the construction of imidazo[1,2-a]pyrimidine-based pyran derivatives I and II. The structures of target compounds were established with different spectroscopic analyses. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Application In Synthesis of 4-Chlororesorcinol).
4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application In Synthesis of 4-Chlororesorcinol
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics