Design, synthesis, and evaluation of novel 3,4-isoxazolediamide derivatives for the combination treatment of azole-resistant candidiasis was written by Liu, Lei;Sun, Yixiang;Gao, Zixuan;Yin, Wenbo;Jiang, Hong;Wu, Tianxiao;Sun, Yin;Qin, Qiaohua;Zhao, Dongmei;Cheng, Maosheng. And the article was included in Archiv der Pharmazie (Weinheim, Germany).Recommanded Product: 4-Chlororesorcinol The following contents are mentioned in the article:
Herein, the structural optimization and structure-activity relationship studies of 3,4-isoxazolediamide analogs I [R1 = 4-FC6H4, 3-isoxazole, benzo(b)thien-2-yl, etc.] and II [R2 = NHMe, NH(i-Pr), NMe2, etc.] were reported. As a new class of fungal Hsp90 inhibitor, compound I [R1 = 5-(morpholinomethyl)isoxazol-3-yl] was found to have good synergistic effects with fluconazole and to avoid potential mammalian toxicity. It also showed remarkable metabolic stability in vitro. Collectively, compound I [R1 = 5-(morpholinomethyl)isoxazol-3-yl] could be a promising lead compound for drug discovery targeting fungal Hsp90 and deserves further investigation. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Recommanded Product: 4-Chlororesorcinol).
4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 4-Chlororesorcinol
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics