Nickel-Catalyzed Reductive Thiolation of Unactivated Alkyl Bromides and Arenesulfonyl Cyanides was written by Wang, Fei;Rao, Weidong;Wang, Shun-Yi. And the article was included in Journal of Organic Chemistry in 2021.Quality Control of 1-Bromo-6-chlorohexane The following contents are mentioned in the article:
The cross-electrophile coupling between unactivated alkyl bromides RBr [R = 2-phenylethyl, but-3-en-1-yl, 1-[(tert-butoxy)(oxo)methane]piperidin-4-yl, etc.] with arenesulfonyl cyanides R1S(O)2CN (R1 = 4-CH3C6H4, C6H5, 4-CH3OC6H4, 4-ClC6H4) catalyzed by Ni(acac)2 under reductive conditions to form unsym. sulfides is developed. This approach for sulfide synthesis is practical, relies on available, unfunctionalized materials such as alkyl (pseudo)halides, and is scalable. This catalytic strategy provides a complementary method for the preparation of unsym. alkyl-aryl sulfides under mild conditions with good functional group tolerance. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Quality Control of 1-Bromo-6-chlorohexane).
1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Quality Control of 1-Bromo-6-chlorohexane
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics