Ag-Catalyzed difluorohydration of β-alkynyl ketones for diastereoselective synthesis of 1,5-dicarbonyl compounds was written by Zhu, Yi-Long;Wang, Ai-Fang;Du, Jian-Yu;Leng, Bo-Rong;Tu, Shu-Jiang;Wang, De-Cai;Wei, Ping;Hao, Wen-Juan;Jiang, Bo. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2017.SDS of cas: 1186603-47-3 The following contents are mentioned in the article:
A new catalytic difluorohydration of β-alkynyl ketones using NFSI as the fluorinating reagent was established, diastereoselectively furnishing a range of structurally diverse difluoride 1,5-dicarbonyl products through C(sp3)-H fluorination. Notably, the sterically encumbered tert-Bu functionality located at the α-position of the carbonyl group of β-alkynyl ketone substrates showed excellent diastereoselectivity (up to >99:1 dr). The reaction enabled multiple bond-forming events including two C(sp3)-F formation through Ag-catalysis to provide a highly efficient and practical method toward difluoride 1,5-dicarbonyls, some of which were successfully converted into difluorinated isoquinolines. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3SDS of cas: 1186603-47-3).
5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.SDS of cas: 1186603-47-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics