Selective α-Methylation of Aryl Ketones Using Quaternary Ammonium Salts as Solid Methylating Agents was written by Templ, Johanna;Schnuerch, Michael. And the article was included in Journal of Organic Chemistry in 2022.Category: chlorides-buliding-blocks The following contents are mentioned in the article:
The use of Ph trimethylammonium iodide (PhMe3NI) as an alternative methylating agent for introducing a CH3 group in α-position to a carbonyl group was described. Compared to conventional methylating agents, quaternary ammonium salts had the advantages of being nonvolatile, noncancerogenic and easy-to-handle solids. This regioselective method was characterized by ease of operational setup, use of anisole as green solvent and yields alkylated aryl ketones RC(O)CH(R1)R2 [R = Ph, 4-BrC6H4, 3-MeOC6H4, etc.; R1 = Me, Et, Bn; R2 = Ph, 4-MeC6H4, 4-FC6H4, etc.] up to 85%. This study involved multiple reactions and reactants, such as Tetramethylammonium chloride (cas: 75-57-0Category: chlorides-buliding-blocks).
Tetramethylammonium chloride (cas: 75-57-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics