Biocatalytic Friedel-Crafts Acylation and Fries Reaction was written by Schmidt, Nina G.;Pavkov-Keller, Tea;Richter, Nina;Wiltschi, Birgit;Gruber, Karl;Kroutil, Wolfgang. And the article was included in Angewandte Chemie, International Edition in 2017.Recommanded Product: 4-Chlororesorcinol The following contents are mentioned in the article:
The Friedel-Crafts acylation is commonly used for the synthesis of aryl ketones, and a biocatalytic version, which may benefit from the chemo- and regioselectivity of enzymes, has not yet been introduced. Described here is a bacterial acyltransferase which can catalyze Friedel-Crafts C-acylation of phenolic substrates in buffer without the need of CoA-activated reagents. Conversions reach up to >99 %, and various C- or O-acyl donors, such as DAPG or isopropenyl acetate, are accepted by this enzyme. Furthermore the enzyme enables a Fries-like rearrangement reaction of resorcinol derivatives These findings open an avenue for the development of alternative and selective C-C bond formation methods. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Recommanded Product: 4-Chlororesorcinol).
4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 4-Chlororesorcinol
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics