Synthesis and Characterization of Impurity B of S-(+)-Clopidogrel Bisulfate: An Antiplatelet was written by Reddy, K. Tatendra;Kumar, K. Suneel;Omprakash, G.;Dubey, P. K.. And the article was included in Synthetic Communications in 2013.Quality Control of (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate The following contents are mentioned in the article:
S-(+)-Clopidogrel bisulfate [(S-(+)-Me 2-(2-chlorophenyl)-2-(6, 7-dihydrothieno[3, 2-c]pyridin-5(4H)-yl)acetate bisulfate)] is a platelet aggregation inhibitor drug. S-(+)-Clopidogrel bisulfate is prepared by different synthetic approaches in the literature. In almost all the approaches the major impurities known in the literature are also listed in the U.S. pharmacopoeia. The control of these pharmaceutical impurities is currently a critical issue to the pharmaceutical industry. In this article, a description of these impurities and their origins in the S-(+)-clopidogrel bisulfate process are presented along with the preparation of impurity B I·HCl. This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Quality Control of (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate).
(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Quality Control of (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics