Vilceanu, R. published the artcileStructure-activity correlations for the toxicity of organic phosphorus compounds of the Schrader type, Quality Control of 866-23-9, the publication is Analele Universitatii din Timisoara, Stiinte Fizice-Chimice (1977), 15(1), 61-77, database is CAplus.
The toxicity in mice of 71 phosphororg. compounds of the Schrader type, R1R2PO2R3, was correlated with parameters for intermol. forces [number of atoms with lone electron pairs (HA), molar refractions (R), Hammett constants of the R3 groups (H), number of aromatic cycles (AR), electron attracting character in charge transfer (CT)] and minimal steric difference (MSD), with respect to acetylcholine. The best linear correlational equation obtained (71 compounds, 6 parameters) was: A = 0.555 + 0.476(HA)-0.017(R) + 0.343(H)-0.402(AR) + 0.611(CT)-0.063(MSD), where A = -lgLD50. This correlation was obtained for a very wide range of chem. structures with the R1, R2 and R3 groups.
Analele Universitatii din Timisoara, Stiinte Fizice-Chimice published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C3H6O2, Quality Control of 866-23-9.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics