Intramolecular Nucleophilic Substitution of ω-Haloalkylphosphine Derivatives was written by Woznicki, Pawel;Korzeniowska, Ewelina;Stankevic, Marek. And the article was included in Journal of Organic Chemistry in 2017.Electric Literature of C6H12BrCl The following contents are mentioned in the article:
ω-Haloalkylphosphine derivatives undergo the intramol. nucleophilic substitution reaction upon treatment with a strong base, yielding either cycloalkylphosphine derivatives or heterocyclic phosphine derivatives The selectivity of the cyclization of (ω-haloalkyl)alkylarylphosphine derivatives depends strongly on the distance between the electrophilic and nucleophilic C atoms and the structure of the P moiety. The desymmetrization of dimethylphenylphosphine sulfide followed by haloalkylation and cyclization led to the enantiomerically enriched tertiary phosphine sulfide, possessing a cyclohexyl fragment at the P. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Electric Literature of C6H12BrCl).
1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Electric Literature of C6H12BrCl
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics