Adding a certain compound to certain chemical reactions, such as: 461432-23-5, name is 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 461432-23-5, HPLC of Formula: C15H14BrClO
50mLAdd to the three-neck bottle4-bromo-1-chloro-2-(4-ethoxybenzyl)benzene (4.9 g, 15 mmol) and tetrahydrofuran 20 mL, stirred and cooled to -5 to 0 C,Slowly add isopropylmagnesium chloride Grignard reagent (8 mL, 2 mol/L).The system was stirred at 0 C for 2 h.In another 100mL three-neck bottle, add(2R,3R,4S,5R,6R)-3,4,5-tribenzyloxy-2-(benzyloxymethyl)-6-bromotetrahydro-2H-pyran (IIc, 6.0 g, 10 mmol) ,Tetramethylethylenediamine (5wt%),Cobalt triacetylacetonate (5 wt%) and 20 mL of tetrahydrofuran,The system was cooled to 0 C.Slowly add the Grignard reagent in the previous 50mL bottle.After about 30 minutes, the addition is completed.The system is warmed to 25 to 30 C.Stir for 2h,The system was quenched with 1N aqueous hydrochloric acid.The organic phase was extracted with EtOAc, brine and evaporated.Column chromatography (PE/EA=9/1),The target product (6.0 g, yield 78%) was obtained.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene, and friends who are interested can also refer to it.
Reference:
Patent; Shanghai Fangnan Biological Technology Co., Ltd.; Zhang Nian; (6 pag.)CN104059041; (2018); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics