The important role of 14490-19-8

14490-19-8, name is 1,4-Dichloropyrido[3,4-d]pyridazine, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 14490-19-8

To l,4-dichloropyrido[3,4-d]pyridazine 3 (4.80 g, 24.0 mmol) and Hnig’sBase (14.7 ml, 84.0 mmol) in NMP (10 ml) was added (2R,5S)-2,5-dimethylpiperazine (4.1 1 g, 36.0 mmol). The reaction was stirred at 100C. After 2 h, the reaction contents were poured into saturated sodium bicarbonate (10x volume) and extracted with dichloromethane (4 x 50 mL). Silica gel chromatography (gradient 0 to 2.5% MeOH in 30% EtOAc in CH2Cl2 with 2.5% TEA additive) provided 1.4 g of l-chloro-4-(rac-2,5-trans-dimethylpiperazin-l-yl)pyrido[3,4- d]pyridazine 43. 1H NMR (500 MHz, CDC13) delta ppm 9.66 (s, 1 H) 9.08 (d, J=5.6 Hz, 1 H) 7.97 (d, J=5.6 Hz, 1 H) 3.77 (tdd, J=I 1.8, 5.9, 3.4 Hz, 1 H) 3.43 (dd, J=12.1, 2.6 Hz, 1 H) 3.17 – 3.32 (m, 2 H) 2.91 (dd, J= 10.5, 2.0 Hz, 1 H) 2.74 (dd, J=I 1.7, 10.3 Hz, 1 H) 1.13 (d, J=6.1 Hz, 3 H) 1.12 (d, J=6.6 Hz, 3 H).

The synthetic route of 14490-19-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AMGEN INC.; WO2009/35568; (2009); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics