Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 461432-23-5, name is 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene, A new synthetic method of this compound is introduced below., COA of Formula: C15H14BrClO
To a solution of aryl bromide 143 (1.50 g, 4.62 mmol) in dry THF (6.2 mE) and dry toluene (24.6 mE) was added dropwise n-butyllithium in n-hexane (1.6 M solution, 5.2 mE, 8.32 mmol) at -78 C. under N2. The reaction mixture was stirred for 30 mm at -78 C. under N2. To this mixture was added triisopropyl borate (1.7 mE, 7.39 mmol) at -78 C. under N2. The temperature of the mixture was allowed to increase to -20 C. over 2 h. To this mixture was added 1M HC1 (aq) (30 mE) at -20 C., and the mixture was stirred at 0 C. for 1 h. The aqueous phase was extracted with EtOAc (4×30 mE) and the combined organic extracts were washed with brine, dried over anhydrous Mg504, and filtered. Concentration of the filtrate followed by flash chromatography (hexane:EtOAc, 2.5:1) yielded aryl boronic acid 124 (684 mg, 51%) as a white solid.
The synthetic route of 461432-23-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; The Chinese University of Hong Kong; Shing, Tony Kung Ming; NG, Wai-Lung; LI, Ho Chuen; LAU, Kit-Man; LAU, Clara Bik San; (39 pag.)US2018/127343; (2018); A1;,
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