29027-20-1, name is 3-Chloro-5-methylaniline, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 29027-20-1
Example XVII; S-chloro-delta-methyl-phenylsulphonyl chloride; A solution of 400 mg of sodium nitrite in 0.6 ml of water is added dropwise to 708 mg 3-chloro-5-methyl-aniline in 2 ml concentrated hydrochloric acid while being cooled in a bath of ice and common salt. The reaction mixture is stirred for 15 minutes at 00C and then added to a mixture of 4 ml of a saturated solution of sulphur dioxide in glacial acetic acid (approx. 30 %) and 200 mg copper(ll)chloride-dihydrate in 0.4 ml of water while being cooled. The cooling bath is removed and the reaction mixture is stirred for 15 minutes at ambient temperature, then at 400C, until no further development of gas can be detected. Then some ice water is added while cooling with an ice bath. After 5 minutes the precipitate formed is suction filtered, washed with some ice water and dried in the desiccator. The sulphonyl chloride obtained is reacted further without any further purification. Yield: 760 mg (68 % of theory)
The synthetic route of 29027-20-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WO2009/30715; (2009); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics