Grob, Cyril A. published the artcilePolar effects. Part II. The transmission of polar effects, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Helvetica Chimica Acta (1977), 60(2), 391-9, database is CAplus.
Comparison of pKa values for the ammonia acids Me3N+(CH2)nCO2H ClO4- (n = 1, 2, 3), I (R = 2-, 3-, 4-CO2H), and II (same R) with the pKa values for the homomorphous acids Me3C(CH2)nCO2H (n = 1, 2, 3), III (R = 2-, 3-, 4-CO2H) and IV (same R) permits an evaluation of the steric effect of the Me3N+ group. The pKa values, corrected for the steric effect, correlate with the reciprocal distance between the pos. N atom and the dissociable proton. Thus, the acidity of these acids is determined by the field effect, not the inductive effect, of the Me3N+ groups.
Helvetica Chimica Acta published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.
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