Itoh, Hiroaki published the artcileControl of the cytotoxicity of dansylated polytheonamide mimic, an artificial peptide ion channel, by modification of the N-terminal structure, SDS of cas: 6249-56-5, the publication is Tetrahedron Letters (2014), 55(3), 728-731, database is CAplus.
We demonstrate that the cytotoxicity of dansylated polytheonamide mimic is controlled by chem. modification of its N-terminal structure. Dansylated polytheonamide mimic is an ion channel peptide which displays potent cytotoxicity against P388 mouse leukemia cells (IC50 = 12 nM). To modulate its cytotoxicity, three analogs of dansylated polytheonamide mimic, possessing distinct N-terminal structures with different hydrophobicities, were synthesized and their cytotoxicities were evaluated. This focused structure-activity relationship study unveiled that the cytotoxicity of dansylated polytheonamide mimic is enhanced 10-fold by simply changing its N-terminal 5,5-dimethyl-2-oxohexanamide to the more hydrophobic palmitamide. The data obtained here provide new understanding for the functional control of the artificial ion channel peptide.
Tetrahedron Letters published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, SDS of cas: 6249-56-5.
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