Shrivash, Manoj K. published the artcileIn-silico designing, chemical synthesis, characterization and in-vitro assessment of antibacterial properties of some analogues of curcumin, SDS of cas: 23616-79-7, the publication is Microbial Pathogenesis (2018), 89-97, database is CAplus and MEDLINE.
In the present work two key regulator proteins, monomeric MipZ of Caulobacter vibrioides (similar to Pseudomonas aeruginosa) and Pyruvate kinase of Staphylococcus aureus were docked with curcumin, the wonder mol. from the spice turmeric and structures of its twelve analogs were designed, synthesized and tested in-vitro for antibacterial activity. Based on the test results a comparative account of the probable mechanism has been given Two major alternative targets are possible for antibacterial activity of drug mols. These may be bacterial cell wall lipids or the proteins responsible for smooth functioning of bacterial cells. In the former case, due to significant difference in the structural components of the cell walls of Gram pos. and Gram neg. bacteria, it is improbable that same ligand will affect both equally. Majority of com. drugs are anti-Gram neg. bacteria while in the present work we have found most effective drugs against Gram pos. bacteria. Based on the test results a comparative account of the probable mechanism has been given. Evidently along with the cell wall damaging mechanism other parallel mechanisms are also operative.
Microbial Pathogenesis published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C5H6BNO2, SDS of cas: 23616-79-7.
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