Gonchar, O. O. published the artcileStudy of antimicrobial qualities of antiseptic remedies, which contain decamethoxin, Safety of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Ukrainian Biopharmaceutical Journal (2016), 74-77, database is CAplus.
In the research the effectiveness of antiseptic remedies, which contain decamethoxin (DCM). Microbicidal (Pilot Manufacturing of Institute of Organic Chem. of National Academy of Sciences of Ukraine) and its remedies’ forms (auridexan (AU), horosten (HS), decasan (DS), septefril (SF). The study was carried out on clin. strains of S. aureus (n 85), E. coli (n 22), P. aeruginosa (n 16), C. albicans (n 12) and was compared with museum strains, got from the museum of alive microbe cultures of Vinnytsya National Pirogov Memorial Medical University. Antimicrobial qualities of antiseptics were studied by means of serial dilutions method. The results of antimicrobial activity of remedies was analyzed by minimal cidal concentration (MCC). We found, that DCM (MCC – 3.67 ± 2.71 mkg/mL), HS (3.44 ± 1.60 mkg/mL, DS (3.06 ± 1.95 mkg/mL), SF (4.32 ± 2.47 mkg/mL) had their microbicidal activity against clin. strains of S. aureus. Such remedies of generic DCM as AU, HS, DS were found to have no difference in antimicrobial activity (p < 0.05). Antimicrobial activity of DCM (MCC – 26.8 ± 17.5 mkg/mL) and its remedies horosten, septefril on clin. strains of E. coli was significantly alike antimicrobial activity of museum strain of E. coli ATCC 25922 (MCC – 7.8-31.25 mkg/mL). Clin. strains of P. aeruginosa were resistant to remedies of generic DCM (MCC – 125-250 mkg/mL). C. albicans were sensitive to remedies of DCM in cidal concentrations 3.9-31.25 mkg/mL. Effective antimicrobial qualities of generic decamethoxin and its remedies (auridexan, horosten, decasan, septefril) are advisable to be used in fighting infection, caused by antibiotocresistant strains of S. aureus, E. coli, C. albicans.
Ukrainian Biopharmaceutical Journal published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Safety of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.
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