Perez-Rodriguez, Santiago published the artcileHighly twisted adamantyl arotinoids: Synthesis, antiproliferative effects and RXR transactivation profiles, SDS of cas: 33697-81-3, the publication is European Journal of Medicinal Chemistry (2009), 44(6), 2434-2446, database is CAplus and MEDLINE.
I (R = H, MeOCH2CH2OCH2; R1 = R2 = H; R1R2 = CH:CH) and II (R = H, MeOCH2CH2OCH2) are prepared as novel adamantyl biaryl arotinoids with decreased binding to retinoic acid receptors but with anticancer activity (by selective induction of apoptosis in cancer cells). I and II are prepared using Suzuki coupling reactions of an adamantylphenylboronic acid with a trifloxyphenylacetate, a trifloxycinnamate, and a trifloxynaphthoate. I (R = H, MeOCH2CH2OCH2; R1 = R2 = H; R1R2 = CH:CH) show significant antiproliferative activity in several human cancer cell lines, with the anticancer activity correlated to the induction of apoptosis as measured by caspase activity. I (R = H, MeOCH2CH2OCH2; R1 = R2 = H; R1R2 = CH:CH), while devoid of retinoic acid receptor binding capacity, transactivate the retinoid X receptor α.
European Journal of Medicinal Chemistry published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, SDS of cas: 33697-81-3.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics