Madhura, V. published the artcileA new route for the synthesis of 4-arylacetamido-2-aminothiazoles and their biological evaluation, Related Products of chlorides-buliding-blocks, the publication is Zeitschrift fuer Naturforschung, B: A Journal of Chemical Sciences (2015), 70(7), 483-489, database is CAplus.
A series of 2-(2-amino-1,3-thiazol-4-yl)-N-phenylacetamides I [R = H, C6H5, 4-MeC6H4, etc.; R1 = H, 2-Me, 3-Cl, 4-Cl] was synthesized in high yields via a single step reaction of ω-bromoacetoacetanilides and thiourea/phenyl thioureas. These synthesized thiazoles I were evaluated for their in vitro antibacterial, antifungal and antioxidant activities. In vitro antimicrobial evaluation of these compounds indicated their specificity towards Gram-pos. species such as S. aureus and E. faecalis. Among the tested compounds, thiazole derivatives I [R = 4-MeC6H4, R1 = H; R = 3-ClC6H4, R1 = H] exhibited the lowest min. inhibitory concentration values against S. aureus and E. faecalis whereas thiazole I [R = 4-MeC6H4; R1 = 4-Cl] showed maximum antioxidant activity. The other compounds exhibited promising antimicrobial and moderate antioxidant activity.
Zeitschrift fuer Naturforschung, B: A Journal of Chemical Sciences published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Related Products of chlorides-buliding-blocks.
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