Oechsner, Regina M. published the artcileAcetate Facilitated Nickel Catalyzed Coupling of Aryl Chlorides and Alkyl Thiols, HPLC of Formula: 637-07-0, the publication is ACS Catalysis (2022), 12(4), 2233-2243, database is CAplus.
A mild, fast, and convenient catalytic system for the coupling of aryl chlorides RCl (R = Ph, pyridin-3-yl, benzodioxol-5-yl, etc.) with primary, secondary, as well as previously challenging tertiary alkyl thiols R1SH (R1 = heptyl, cyclohexyl, adamantan-1-yl, etc.) uses an air-stable nickel(II) precatalyst in combination with the low-cost base potassium acetate at room temperature The catalytic system tolerates a variety of functional groups and enables the generation of thioethers for a wide range of substrates, including pharmaceutical compounds RSR1 in excellent yields. Chemoselective functionalization of disubstituted substrates was demonstrated. Kinetic and NMR studies, as well as DFT computations support a Ni(0)/Ni(II) catalytic cycle and identify the oxidative addition product as the resting state. Acetate coordination and subsequent acetate facilitated the formation of a thiolate complex via internal deprotonation and play a key role in the catalytic cycle.
ACS Catalysis published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, HPLC of Formula: 637-07-0.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics