Downie, Ian M.’s team published research in Tetrahedron in 38 | CAS: 866-23-9

Tetrahedron published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Safety of Diethyltrichloromethylphosphonate.

Downie, Ian M. published the artcileA high yield route to ethyl esters of carboxylic acids, Safety of Diethyltrichloromethylphosphonate, the publication is Tetrahedron (1982), 38(10), 1457, database is CAplus.

On treatment with (EtO)2POCCl3 (I), aromatic and aliphatic carboxylic acids gave the corresponding Et esters in good-to-high yield through transesterification. E.g., treatment of PhCO2H with I, prepared in 92% yield from (EtO)3P and CCl4, at 120° for 1 day gave 96% PhCO2Et. 2,4,6-Me3C6H2CO2H was esterified in 93% yield.

Tetrahedron published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Safety of Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics