Hou, Xuehui published the artcileDesign, synthesis and bioactivities evaluation of novel quinazoline analogs containing oxazole units, Application In Synthesis of 350-30-1, the publication is Chinese Journal of Chemistry (2014), 32(6), 538-544, database is CAplus.
Novel quinazoline derivatives I (R = PhOCH2, Me), which were designed by the combination of quinazoline as the backbone and oxazole scaffold as the substituent, were synthesized and their biol. activities evaluated for anti-proliferative activities and EGFR inhibitory potency. Enantiomer (R)-I (R = PhOCH2) demonstrated the most potent inhibitory activity (IC50=0.95 μmol/L for EGFR), which could be optimized as a potential EGFR inhibitor in the further studies.
Chinese Journal of Chemistry published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Application In Synthesis of 350-30-1.
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Chlorides – an overview | ScienceDirect Topics