Stergiopoulos, Chrysanthos published the artcileThe use of biomimetic chromatography to predict acute aquatic toxicity of pharmaceutical compounds, Application of Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, the publication is Toxicological & Environmental Chemistry (2022), 104(1), 1-19, database is CAplus.
The potential of biomimetic chromatog. to predict ecotoxicol. endpoints of pharmaceutical compounds was investigated. For this purpose, a data set of previously and newly measured chromatog. retention data for 36 structurally diverse drugs was used. Standardized retention times were measured on the immobilized artificial membrane, human serum albumin, and alpha-1-acid glycoprotein stationary phases. As ecotoxicol. endpoints, half-maximal lethal concentration values of fish and half-maximal effective concentration (immobilization) values of a water flea (Daphnia magna spp.) determined with a two-day static method were considered. Ecotoxicity values correlated with octanol-water partitioning and the pos. charge of compounds contributed even more to the toxicity. Models based on membrane partition exhibited the best statistics and predictive performance, attributed to lipophilicity and membrane electrostatic interactions. Alpha-1-acid glycoprotein binding led to satisfactory models, owing to its function as a binder of neutral and basic lipophilic compounds Albumin binding, however, did not result in sound models, as it is governed by lipophilicity and the neg. charge of compounds, contrary to the mechanism of toxicity. Both membrane and alpha-1-acid glycoprotein models were superior statistically from those derived from the octanol-water system. Overall, membrane and alpha-1-acid glycoprotein retention can be suggested as promising indexes to assess the ecotoxicol. risk of drugs.
Toxicological & Environmental Chemistry published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C7H5BClNO2, Application of Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate.
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