Rowbottom, Martin W. published the artcileSynthesis and structure-activity relationships of biarylcarboxamide bis-aminopyrrolidine urea derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1), Computed Properties of 145349-62-8, the publication is Bioorganic & Medicinal Chemistry Letters (2005), 15(14), 3439-3445, database is CAplus and MEDLINE.
A novel series of bis-aminopyrrolidine ureas containing either a 4-biphenylcarboxamide or 5-phenyl-2-thiophenecarboxamide group have been identified as potent and functional antagonists of the melanin-concentrating hormone receptor-1. Syntheses and SAR are described, which led to the discovery of compounds with high binding affinity (Ki = 1 nM) for the receptor. Preliminary in vitro metabolic stability data are also reported for key compounds
Bioorganic & Medicinal Chemistry Letters published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Computed Properties of 145349-62-8.
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