Pd-catalyzed amidation of 1,3-diketones with CO and azides via a nitrene intermediate was written by Gu, Zheng-Yang;Chen, Jie;Xia, Ji-Bao. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020.Reference of 3438-16-2 This article mentions the following:
An efficient Pd-catalyzed amidation of 1,3-diketones has been developed using carbon monoxide and organic azides. This reaction provides a step-economic approach to produce β-ketoamides from readily available compounds under mild ligand-, oxidant-, and base-free conditions. The mechanistic studies showed that the reaction occurred through an in situ generated isocyanate intermediate. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Reference of 3438-16-2).
5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Reference of 3438-16-2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics