Construction of axial chirality via asymmetric radical trapping by cobalt under visible light was written by Jiang, Xuan;Xiong, Wei;Deng, Shuang;Lu, Fu-Dong;Jia, Yue;Yang, Qian;Xue, Li-Yuan;Qi, Xiaotian;Tunge, Jon A.;Lu, Liang-Qiu;Xiao, Wen-Jing. And the article was included in Nature Catalysis in 2022.Related Products of 620-19-9 This article mentions the following:
The 3d metals have been identified as economic and sustainable alternatives to palladium, the frequently used metal in transition-metal-catalyzed cross-couplings. However, cobalt has long stood behind its neighboring elements, nickel and copper,in asym. radical couplings owing to its high catalytic activity in the absence of ligands resulting in unfavorable un-asym. background reactions. Here, the authors disclose an asym. metallaphotoredox catalysis (AMPC) strategy for the dynamic kinetic asym. transformation of racemic heterobiaryls, which represents a visible-light-induced, asym. radical coupling for the construction of axial chirality. This success can also extended to the reductive cross-coupling variant featuring the use of more easily available organic halide feedstocks. The keys to these achievements are the rational design of a sustainable AMPC system that merges asym. cobalt catalysis with organic photoredox catalysis in combination with the identification of an efficient chiral polydentate ligand. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Related Products of 620-19-9).
1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Related Products of 620-19-9
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics