Synthesis of novel (E)-2-(4-(1H-1,2,4-triazol-1-yl)styryl)-4-(alkyl/arylmethyleneoxy)quinazoline derivatives as antimicrobial agents was written by Yang, Lan;Ge, Shijia;Huang, Jian;Bao, Xiaoping. And the article was included in Molecular Diversity in 2018.Safety of 1-(Chloromethyl)-3-methylbenzene This article mentions the following:
A series of novel (E)-2-(4-(1H-1,2,4-triazol-1-yl)styryl)-4-(alkyl/arylmethyleneoxy)quinazoline derivatives I (R = H, Me, Et, etc.) were synthesized in good to excellent yields. The structure of compound I (R = Me) was further confirmed via single-crystal X-ray diffraction anal. The bioassay results indicated that compounds I (R = 4-t-Bu-C6H4, 2,6-(Cl)2C6H3, 4-FC6H4) inhibit phytopathogenic bacterium Xanthomonas axonopodis pv. citri (Xac) more potently than com. bactericide bismerthiazol. However, not a single compound effectively inhibited the three pathogenic fungi tested at 50 μg/mL. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Safety of 1-(Chloromethyl)-3-methylbenzene).
1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Safety of 1-(Chloromethyl)-3-methylbenzene
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics