Sydnone Sulfonamide Derivatives as Antibacterial, Antifungal, Antiproliferative and Anti-HIV Agents was written by Asundaria, Shahrukh T.;Pannecouque, Christophe;De Clercq, Erik;Patel, Keshav C.. And the article was included in Pharmaceutical Chemistry Journal in 2014.Quality Control of 2-Chloro-6-nitrobenzoic acid This article mentions the following:
Three series of substituted sydnone sulfonamide derivatives were synthesized wherein 3-(4-methylphenyl)-4-(chlorosulfonyl)sydnone was linked by a sulfonamide linkage with various thiazole, benzothiazole and quinazoline groups. The structures of the compounds were confirmed by IR and NMR spectroscopy and elemental anal. The synthesized compounds were evaluated for their antibacterial, antifungal, antiproliferative and anti-HIV activities. Anti-HIV activity was determined against human immunodeficiency virus HIV-1 (III-B) and HIV-2 (ROD) in MT-4 cells. Inhibition of cytomegalovirus and varicella-zoster virus (VZV) replication was measured in human embryonic lung (HEL) cells. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0Quality Control of 2-Chloro-6-nitrobenzoic acid).
2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Quality Control of 2-Chloro-6-nitrobenzoic acid
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics