Munia, Nasrin S. et al. published their research in Nucleosides, Nucleotides & Nucleic Acids in 2022 | CAS: 76-83-5

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Recommanded Product: 76-83-5

Synthesis, antimicrobial, SAR, PASS, molecular docking, molecular dynamics and pharmacokinetics studies of 5′-O-uridine derivatives bearing acyl moieties: POM study and identification of the pharmacophore sites was written by Munia, Nasrin S.;Hosen, Mohammed A.;Azzam, Khaldun M. A.;Al-Ghorbani, Mohammed;Baashen, Mohammed;Hossain, Mohammed K.;Ali, Ferdausi;Mahmud, Shafi;Shimu, Mst. S. S.;Almalki, Faisal A.;Hadda, Taibi B.;Laaroussi, Hamid;Naimi, Souad;Kawsar, Sarkar M. A.. And the article was included in Nucleosides, Nucleotides & Nucleic Acids in 2022.Recommanded Product: 76-83-5 This article mentions the following:

Novel uridine derivatives were designed and synthesized. The chem. structures and purity of these new uridine derivatives were confirmed by usual spectroscopic techniques. In vitro antimicrobial activity and SAR study was investigated. The incorporation of various aliphatic and aromatic groups in uridine structure significantly increased their biol. activity. PASS prediction anal. indicated that the compounds were less potent as anti-carcinogenic agents (0.31 < Pa < 0.52) than as antimicrobial agents. Mol. docking anal. showed that the novel uridine derivatives may possess excellent effectiveness for lanosterol 14a-demethylase CYP51A1 (3JUV) and Aspergillus flavus (1R4U). The stability of the docked complex was confirmed by performing mol. dynamics along with an estimation of MMPB/GBSA binding free energy which ensured that complex of some 5′-O-uridine derivatives were reported in improved dynamics stability as revealed by their uniform RMSD and RMSF profiles. In silico ADMET calculations predicted improved pharmacokinetic properties of all uridine derivatives The POM anal. showed the presence of an antifungal (O δ- — O′ δ-) pharmacophore site. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Recommanded Product: 76-83-5).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Recommanded Product: 76-83-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics