1996-30-1, Name is 3-Bromo-4-fluorochlorobenzene, 1996-30-1, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
To a solution of 2-bromo-4-chloro-1 -fluorobenzene (1 .03 g, 4.94 mmol) in tetrahydrofuran (20 ml_) at -78 C was added n-butyllithium (4.0 ml_, 9.88 mmol) under nitrogen. The reaction mixture was stirred at -78 C for 2 h before a solution of 6-(4-methoxybenzylamino)pyridazine-3-carbaldehyde (0.800 g, 3.29 mmol) in tetrahydrofuran (3 ml_) was added dropwise. The reaction mixture was stirred for another 2 h and was warmed to 20 C. Aqueous ammonium chloride was added to quench the reaction and the volatiles were removed under reduced pressure. The aqueous layer was extracted with dichloromethane (50 ml_ x 2). The combined organic layers were dried over sodium sulfate, filtered and concentrated. The crude sample was purified by column chromatography (silica gel, petroleum ether/ethyl acetate = 4/1 to 1 /1 ) to give (5-chloro-2-fluorophenyl)(6-(4-methoxybenzylamino)pyridazin-3-yl)methanol (0.330 g, 0.888 mmol, 27%) as a yellow solid. LCMS (ESI) m/z: 374.0 [M+H]+.
Statistics shows that 3-Bromo-4-fluorochlorobenzene is playing an increasingly important role. we look forward to future research findings about 1996-30-1.
Reference:
Patent; YUMANITY THERAPEUTICS, INC.; LE BOURDONNEC, Bertrand; LUCAS, Matthew; OZBOYA, Kerem; PANDYA, Bhaumik; TARDIFF, Daniel; TIVITMAHAISOON, Parcharee; WRONA, Iwona; (475 pag.)WO2019/183587; (2019); A1;,
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