Water at elevated temperatures (WET): reactant, catalyst, and solvent in the selective hydrolysis of protecting groups was written by Medina-Ramos, Wilmarie;Mojica, Mike A.;Cope, Elizabeth D.;Hart, Ryan J.;Pollet, Pamela;Eckert, Charles A.;Liotta, Charles L.. And the article was included in Green Chemistry in 2014.Recommanded Product: tert-Butyl (4-chlorophenyl)carbamate This article mentions the following:
Water at elevated temperatures (WET) can act simultaneously as reactant, solvent, and catalyst in reaction processes. WET was successfully employed in the removal of protecting groups alleviating the need for added strong acids/bases, subsequent neutralization and waste salt elimination. The protocols for the water-mediated removal of several common protecting groups such as tert-Bu carbamates (N-Boc) from 125 to 150°, acetamide (N-Ac) at 275° and acetate esters (O-Ac) at 250° are reported for different model aryl compounds High yields and selective deprotection of one protecting group in the presence of another by simply tuning the temperature is demonstrated. To gain further insights into reaction processes, the aqueous solubilities of several of the reactants, the kinetics and mechanisms associated with some of these reactions are also discussed. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Recommanded Product: tert-Butyl (4-chlorophenyl)carbamate).
tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: tert-Butyl (4-chlorophenyl)carbamate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics