Vergelli, Claudia et al. published their research in Journal of Enzyme Inhibition and Medicinal Chemistry in 2017 | CAS: 1711-11-1

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Formula: C8H4ClNO

Isoxazol-5(2H)-one: a new scaffold for potent human neutrophil elastase (HNE) inhibitors was written by Vergelli, Claudia;Schepetkin, Igor A.;Crocetti, Letizia;Iacovone, Antonella;Giovannoni, Maria Paola;Guerrini, Gabriella;Khlebnikov, Andrei I.;Ciattini, Samuele;Ciciani, Giovanna;Quinn, Mark T.. And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2017.Formula: C8H4ClNO This article mentions the following:

Human neutrophil elastase (HNE) is an important target for the development of novel and selective inhibitors to treat inflammatory diseases, especially pulmonary pathologies. Here, the authors report the synthesis, structure-activity relationship anal., and biol. evaluation of a new series of HNE inhibitors with an isoxazol-5(2H)-one scaffold. The most potent compound (2o) (3-isopropyl-2-(4-methylbenzoyl)isoxazol-5(2H)-one) had a good balance between HNE inhibitory activity (IC50 value =20 nM) and chem. stability in aqueous buffer (t1/2=8.9 h). Anal. of reaction kinetics revealed that the most potent isoxazolone derivatives were reversible competitive inhibitors of HNE. Furthermore, since compounds (2o) and (2s) (3-isopropyl-2-(4-(trifluoromethyl)benzoyl)isoxazol-5(2H)-one) contain two carbonyl groups (2-N-CO and 5-CO) as possible points of attack for Ser 195, the amino acid of the active site responsible for the nucleophilic attack, docking studies allowed the authors to clarify the different roles played by these groups. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Formula: C8H4ClNO).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Formula: C8H4ClNO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics