5-Amino-2,4-dichlorophenol (cas: 39489-79-7) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application In Synthesis of 5-Amino-2,4-dichlorophenol
Metabolism of 2,4-, 2,5-, and 3,4-dichloronitrobenzene in the rabbit was written by Bray, H. G.;James, Sybil P.;Thorpe, W. V.. And the article was included in Biochemical Journal in 1957.Application In Synthesis of 5-Amino-2,4-dichlorophenol This article mentions the following:
The metabolism of 2,4-, 2,5-, and 3,4-dichloronitrobenzene has been studied in the rabbit. The main products excreted in urine are mercapturic acids (corresponding to 30-50% of the dose) and phenols conjugated with glucuronic and sulfuric acids. Smaller amounts of dichloroanilines are excreted. The mercapturic acids have been isolated and their structure has been confirmed by synthesis. In each case they are formed by substitution of the labile Cl. 2-Bromo-4-chloro-, 2-bromo-5-chloro-, and 4-bromo-3-chloronitrobenzene when fed to rabbits yield the same mercapturic acids as do the corresponding dichloronitrobenzenes. The following nitro- and aminodichlorophenols excreted have been identified: N-acetyl-S-(5-chloro-2-nitrophenyl)-L-cysteine, m. 192°, [α]D20 in EtOH + 63 ± 3°, absorption maximum 253 mμ, 375, N-acetyl-S-(4-chloro-2-nitrophenyl)-L-cysteine 161-2, 104 ± 7, 249, 390; N-acetyl-S-(2-chloro-4-nitrophenyl)-L-cysteine 192-194, -4 ± 4, 345; 2,4-, 2,5- and 3,4-dichloroaniline, 2,4-dichloro-5-nitrophenol, 3,5-dichloro-2-nitrophenol, 2-amino-3,5-dichlorophenol, 3-amino-2,6-dichlorophenol, 5-amino-2,4-dichlorophenol, 2,5-dichloro-4-nitrophenol, 3-amino-2,5-dichlorophenol, 4-amino-2,5-dichlorophenol, 2-aminodichlorophenol, 5-amino-2,3-dichlorophenol. Rf values in 3 solvents have been determined for the various possible metabolites of the dichloronitrobenzenes. 3,3′,4,4′-Tetrachloroazoxybenzene has been isolated from the urine of rabbits given 3,4-dichloronitrobenzene. The difference between the metabolic fates of the dichloronitrobenzenes and those of the monochloronitrobenzenes are discussed. Mercapturic acid formation provides the major metabolite pathway for the dichloro compounds and hydroxylation is the principal metabolite process for the monochloro compounds In the experiment, the researchers used many compounds, for example, 5-Amino-2,4-dichlorophenol (cas: 39489-79-7Application In Synthesis of 5-Amino-2,4-dichlorophenol).
5-Amino-2,4-dichlorophenol (cas: 39489-79-7) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application In Synthesis of 5-Amino-2,4-dichlorophenol
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics