A common compound: 627-42-9, name is 2-Methoxyethyl chloride, belongs to chlorides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 627-42-9
(Ph2SiH)2 (0.10g, 0.27mmol) and B(C6F5)3 (0.015g, 0.029mmol) were combined with toluene (1mL) in a Schlenk flask. 2-Chloroethyl methyl ether (0.050mL, 0.55mmol) was added dropwise with stirring, and the resulting mixture was stirred under N2 (open to the nujol bubbler) for 16h, by which time it was cloudy white. The toluene was removed under vacuum and cold pentane (2mL) was added, giving a white precipitate. The precipitate was collected by filtration, washed with cold pentane (4mL), and dried under vacuum, giving a white powdery solid (0.094g, 65%). 1H NMR (300MHz, C6D6) delta 3.17 (t, 3JHH=6Hz, 4H, OCH2CH2Cl), 3.77 (t, 4H, OCH2CH2Cl), 7.14 (m, 12H, Hm/p-SiPh2), 7.75 (m, 8H, Ho-SiPh2); 13C NMR (75MHz, C6D6) delta 45.1 (OCH2CH2Cl), 64.8 (OCH2CH2Cl), 128.2 (Cm-SiPh2), 130.3 (Cp-SiPh2), 135.4 (Co-SiPh2). 29Si NMR (99MHz, C6D6) delta-7.7. M.p. 138-140C. Anal. (calcd for 93% C28H28O2Cl2Si2 (18) and 7% C2H6OSi (grease)): C 63.28 (63.23) H 5.17 (5.36).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 627-42-9, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Lee, Peter T.K.; Rosenberg, Lisa; Journal of Organometallic Chemistry; vol. 809; (2016); p. 86 – 93;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics