[2]Rotaxane Formation by Transition State Stabilization was written by De Bo, Guillaume;Dolphijn, Guillaume;McTernan, Charlie T.;Leigh, David A.. And the article was included in Journal of the American Chemical Society in 2017.Reference of 2168-06-1 This article mentions the following:
We report on the synthesis of [2]rotaxanes driven by stabilization of the axle-forming transition state. A bifunctional macrocycle, with hydrogen bond donors at one end and acceptors at the other, is used to stabilize the charges that develop during the addition of a primary amine to a cyclic sulfate. In the experiment, the researchers used many compounds, for example, 3,3,3-Tris(4-chlorophenyl)propionic acid (cas: 2168-06-1Reference of 2168-06-1).
3,3,3-Tris(4-chlorophenyl)propionic acid (cas: 2168-06-1) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Reference of 2168-06-1
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics