Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.2516-96-3, Name is 2-Chloro-5-nitrobenzoic acid, SMILES is C1=C([N+]([O-])=O)C=CC(=C1C(=O)O)Cl, belongs to chlorides-buliding-blocks compound. In a document, author is Fawcett, Alexander, introduce the new discover, Category: chlorides-buliding-blocks.
Site Selective Chlorination of C(sp(3))-H Bonds Suitable for Late-Stage Functionalization
C(sp(3))-Cl bonds are present in numerous biologically active small molecules, and an ideal route for their preparation is by the chlorination of a C(sp(3))-H bond. However, most current methods for the chlorination of C(sp(3))-H bonds are insufficiently site selective and tolerant of functional groups to be applicable to the late-stage functionalization of complex molecules. We report a method for the highly selective chlorination of tertiary and benzylic C(sp(3))-H bonds to produce the corresponding chlorides, generally in high yields. The reaction occurs with a mixture of an azidoiodinane, which generates a selective H-atom abstractor under mild conditions, and a readily-accessible and inexpensive copper(II) chloride complex, which efficiently transfers a chlorine atom. The reaction’s exceptional functional group tolerance is demonstrated by the chlorination of >30 diversely functionalized substrates and the late-stage chlorination of a dozen derivatives of natural products and active pharmaceutical ingredients.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 2516-96-3 is helpful to your research. Category: chlorides-buliding-blocks.