Adding some certain compound to certain chemical reactions, such as: 627-42-9, name is 2-Methoxyethyl chloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 627-42-9. 627-42-9
the 121g (leq) ELTA 1200ml and dimethylformamide (DMF) was stirred clear solution; sequentially added 323g (4eq) 2- chloroethyl methyl ether, 944g (8eq) of anhydrous potassium carbonate and 23.6gTetrabutylammonium bromide; purged with nitrogen three times,Under nitrogen, the reaction was heated to 105~110 C 13~14h; the filter cake was rinsed DCM until the filtrate was colorless; the combined filtrate was concentrated under reduced pressure to a fraction distilled off; the residue was added DCM, cooled to room temperature , washed with 3Nu K0H, the DCM phase was separated, washed with water, brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to 45 C to give 210g oil ELTB, yield 96.4%
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2-Methoxyethyl chloride.
Reference:
Patent; Chongqing Peng Wei Pharmaceutical Co., Ltd.; Yan, Weiwei; Ren, Yanrong; Liu, Zeyan; Han, Gongchao; (9 pag.)CN105566233; (2016); A;,
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