Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 60811-18-9, name is 4-Bromo-1-chloro-2-fluorobenzene, A new synthetic method of this compound is introduced below., 60811-18-9
(5) Metal magnesium in an amount of 1.2 g was suspended in 20 ml of THF under nitrogen gas stream, and a solution prepared by dissolving 9.6 g of 3-fluoro-4-chloro-bromobenzene in 50 ml of THF was added dropwise thereto and stirred at room temperature for 1 hour to prepare a solution of Grignard reagent. In 30 ml of THF was dissolved 9.7 g of the 4-(trans-4-(2-(trans-4-n-propylcyclohexyl)ethyl)cyclohexyl)iodobenzene mentioned above, 1 g of palladium chloride was added thereto, and they were stirred under a reflux. The Grignard reagent prepared by the procedures mentioned above was added dropwise thereto and they were reacted while stirring for 2 hours. Reaction solution thus obtained was added to 100 ml of dilute hydrochloric acid and the product was extracted with 100 ml of heptane. Organic layer was washed with water and dried over anhydrous magnesium sulfate, and the solvent was distilled off under a reduced pressure to obtain a yellow-brown oily product. This product was purified by a column chromatography over an alumina by using heptane as an eluent. Further, the product was recrystallized from heptane to obtain 2.3 g of the subject compound. CN 138.1, NI 227.7 According to the procedures mentioned above, following Compounds No. 2 to No. 63 were synthesised:
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Chisso Corporation; US5858275; (1999); A;,
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