Analyzing the synthesis route of 1-Bromo-4-chlorobutane

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6940-78-9, name is 1-Bromo-4-chlorobutane, This compound has unique chemical properties. The synthetic route is as follows., 6940-78-9

A. Preparation of the intermediate compounds; Example AlA; a) Preparation of intermediate 1; To a stirred solution of Grignard reagent at 5C, prepared from Mg turnings (0.14 mol) and l-bromo-4-chlorobutane (0.14 mol) in diethylether (150 ml), was added dropwise a solution of 2-naphthylcarboxaldehyde (0.0935 mol) in TEtaF (150 ml). After the mixture was stirred for 4 hours at 5C a solution of ammonium chloride (10% aqueous) was added slowly. The organic layer was separated, washed with brine, dried over EPO magnesium sulfate, filtered, and the solvent was evaporated. The residue was purified by column chromatography over silica gel (eluent: cyclohexane/EtOAc : 90/10 ; 15-40 mum). The pure fractions were collected and the solvent was evaporated. Yield : 8.2 g of intermediate 1 (35%).

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Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2007/435; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics