Related Products of 69411-05-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 69411-05-8, name is 3-Chloro-5-trifluoromethylaniline, This compound has unique chemical properties. The synthetic route is as follows.
11636] 3-Chloro-5-trifluoromethylaniline (517, 3.66 g,18.7 mmol) was dissolved in 70 mE THF and stirred in an ice bath. To it were added 13oC2O (4.48 g, 20.6 mmol) and DMAP (2.51 g, 20.6 mmol). The mixture was stirred for overnight, and was concentrated in vacuo. The residue was taken into 200 mE EtOAc, washed with water x3, dried, rotavaped, and subjected to silica flash colunm using 1% MeOR in DCM to get tert-butyl 3-chloro-5-(trifluoromethyl) phenylcarbamate (518, 3.37 g, 61%) as a white solid. It was dissolved in 100 mE dry THF and treated with NaR (60% in mineral oil, 910 mg, 22.8 mmol) at RT for 15 mm and then iodomethane (1.42 mE, 22.8 mmol) was added. The mixture was stirred for overnight, concentrated, taken into 200 mE EtOAc, washed with water x2, dried, concentrated, and subjected to silica flash column using 0 to 5% EtOAc in DCM to isolate the methylation product as an oil. It was treated with 1:1 TFADCM (10 mE/i 0 mE) at RT for 3 hours, concentrated in vacuo, taken into 200 mE EtAOc and 50 mE iN NaOH. The organic phase was separated, washed with water, dried, subjected to silica flash column with 1% MeOR in DCM to isolate 3-chioro-N-methyl-5-(trifluoromethyl) aniline (519, 1.76 g, 53%) as an oil.
The chemical industry reduces the impact on the environment during synthesis 3-Chloro-5-trifluoromethylaniline. I believe this compound will play a more active role in future production and life.
Reference:
Patent; JIA, Zhaozhong J.; CHEN, Wei; THOMAS, William D.; US2015/158865; (2015); A1;,
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