Adding some certain compound to certain chemical reactions, such as: 6579-54-0, name is 2,6-Dichlorobenzenesulfonyl chloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6579-54-0. 6579-54-0
General procedure: A mixture of N-Boc-aminol (1 eq.) and KOH (3eq) in THF was stirred vigorously for 15 min. It was followed by the addition of required benzenesulfonyl chloride derivative (1.2eq) and subsiquent stirring of the reaction for 4-5h. After completion of the reaction (as per TLC), the reaction mixture was filtered to expel out the precipitated salt and the filterate thus obtained was concentrated under reduced pressure to obtain the crude product which was further purified by column chromatography (eluent EtOAc:Hexane).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2,6-Dichlorobenzenesulfonyl chloride.
Reference:
Article; Saxena, Anil K.; Sharma, Sugandha; Pandey, Atindra K.; Shukla, Praveen K.; Bioorganic and Medicinal Chemistry Letters; vol. 21; 21; (2011); p. 6476 – 6481;,
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