29027-20-1, name is 3-Chloro-5-methylaniline, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 29027-20-1
to the mixture of solid (400 mg, 1.66 mmol) from Step 2-1 and MeOH (15 mL) was added 3-chloro-5-methylaniline (0.21 mL, 1.66 mmol), formic acid (0.064 mL, 1.66 mmol) and l-(2,2-dimethoxy-ethyl)-2- isocyano-benzene ( 0.32 mL, 2.5 mmol). The resulting mixture was heated at 50 C overnight. The reaction solution was concentrated and dried under high vacuum to give brown solid as the desired product (60% pure). The crude material was used for next step without further purification.
The synthetic route of 29027-20-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CRINETICS PHARMACEUTICALS, INC.; ZHAO, Jian; ZHU, Yunfei; WANG, Shimiao; HAN, Sangdon; KIM, Sun Hee; (109 pag.)WO2017/3724; (2017); A1;,
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