Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2106-02-7, name is 2-Chloro-4-fluoroaniline, A new synthetic method of this compound is introduced below., Recommanded Product: 2106-02-7
In another 1L four-neck reaction flask, under the protection of nitrogen, 219.54 g of tetrahydrofuran was added in sequence.77.43g (0.532mol) 2-chloro-4-fluoroaniline, 0.73g (0.00532mol) zinc chloride, 0.29g (0.000532mol) (dppp)NiCl2, stirring, the reaction system is cooled to 10 ~ 15 C, dripping Add the 3,4-dichlorophenylmagnesium bromide Grignard reagent produced in step 1 to the system, keep the temperature at 10-15 C, add the dropwise time for 3 hours, add dropwise, and keep warm for 4 h.After the sampling and detection reaction was completed, dilute hydrochloric acid was added dropwise to the reaction liquid, the reaction was quenched, stirred for 10 min, allowed to stand, layered, and the organic layer was washed with a 5% sodium chloride solution.The mixture was allowed to stand for stratification, and the organic layer was added with activated carbon, heated to reflux, filtered while hot, and the filtrate was concentrated under reduced pressure to remove tetrahydrofuran.So far, the temperature was lowered to 20 to 25 C to obtain a white flake solid, which was 3′,4′-dichloro-5-fluoro-2-aminobiphenyl, and the solid was weighed to 123.4 g, and the yield was 90.6% (by 2- Chloro-4-fluoroaniline), purity (GC) ? 99.0%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Lianhua Science And Technology (Shanghai) Co., Ltd.; Lianhua Technology Co., Ltd.; Liaoning Tian Yu Chemical Co., Ltd.; Hubei Jun Tai Pharmaceutical And Chemical Co., Ltd.; Fan Xiaobin; Guo Zhanghong; Jiang Peng; (18 pag.)CN105198682; (2018); B;,
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