Extracurricular laboratory: Synthetic route of

Related Products of 29671-92-9,Some common heterocyclic compound, 29671-92-9, name is Carbamimidic chloride hydrochloride, molecular formula is CH4Cl2N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 7 Synthesis of 2-amino-8-chloro-3H-benzo[4,5]furo[3,2-d]pyrimidin-4-one; To a solution of S-amino-S-chlorobenzofuran-l-carboxylic acid methyl ester (5.0 g, 22.16 mmol, 1 eq) in sulfolane (25 ml) is added chloroformamidine hydrochloride (3.82 g, 33.24 mmol, 4.5 eq) at 100 0C and the reaction mixture is stirred further at 160 0C for an hour, it is cooled down to 50 0C and diluted with methanol (75 ml), the precipitated product is filtered off, dried in vacuo at 80 0C. A yellowish solid (3.85 g, 16.34 mmol, 73.73%) is obtained.1H NMR (DMSO-de): 7.67 (dd, IH), 7.82 (d, IH), 8.06 (d, IH)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Carbamimidic chloride hydrochloride, its application will become more common.

Reference:
Patent; CELLZOME (UK) LTD.; WO2008/62013; (2008); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics