Application of 72235-58-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 72235-58-6 as follows.
Example 7; 3- [5,6-Bis(methyloxy)-2-pyridinyll -N- [(4-chloro-3-fluorophenvDmethyll -2,4-dioxo-l ,2,3,4- tetrahvdrothieno[3,2-|pyrimidine-6-carboxamideTo a mixture of 3-[5,6-bis(methyloxy)-2-pyridinyl]-2,4-dioxo- 1,2,3,4- tetrahydrothieno[3,2-d]pyrimidine-6-carboxylic acid (Id, 87 mg, 0.25 mmol), [(4-chloro-3- fluorophenyl)methyl] amine (59.8 mg, 0.375 mmol), and 2-chloro-l,3-dimethylimidazolinium chloride (63.4 mg, 0.375 mmol) in N,N-dimethylformamide (DMF) (2.00 ml) was added DIEA (0.065 ml, 0.375 mmol). The mixture was stirred at room temperature overnight and purified by reversed-phase HPLC to provide 3-[5,6-bis(methyloxy)-2-pyridinyl]-N-[(4-chloro-3- fluorophenyl)methyl]-2,4-dioxo- 1 ,2,3,4-tetrahydrothieno[3,2-Patent; GLAXOSMITHKLINE LLC; SCHULZ, Mark, James; WANG, Younghui; GHERGUROVICH, Jonathan M.; WO2010/59555; (2010); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics